Table Of Contents
- Fioricet Price Comparison Table
- Fioricet Information
- Fioricet Ingredients and Composition
- How To Take Fioricet and Fioricet Dosage and Administration
- If you suspect a Fioricet Overdose
- Fioricet Side Effects
- Fioricet Precautions and Contraindications
- Fioricet Drug Interactions
- Taking Fioricet during Pregnancy or Breast-feeding
- Fioricet Addiction and Abuse
- Storing Fioricet
- Additional Notes
- Articles and information related to Fioricet
- Credits for Fioricet Information
Brand names: Fioricet, Esgic-Plus
Fioricet Price Comparison Table
| Product | Qty | Medical Fees & Shipping | Price/ Qty | Price | Click to Order |
|---|---|---|---|---|---|
| Fioricet 325mg | 60 | $18.00 | $2.48ea | $149.00 | Buy from IntegraRx |
| Fioricet 325mg | 100 | $18.00 | $1.79ea | $179.00 | Buy from IntegraRx |
| Product | Qty | Medical Fees & Shipping | Price/ Qty | Price | Click to Order |
|---|---|---|---|---|---|
| Fioricet 50/325/40mg | 30 | $18.00 | $3.14ea | $94.30 | Buy from MPllc |
| Fioricet 50/325/40mg | 60 | $18.00 | $2.00ea | $119.95 | Buy from MPllc |
| Fioricet 50/325/40mg | 90 | $18.00 | $2.00ea | $179.95 | Buy from MPllc |
| Product | Qty | Medical Fees & Shipping | Price/ Qty | Price | Click to Order |
|---|---|---|---|---|---|
| Fioricet 40mg | 30 | $15.00 | $3.33ea | $99.95 | Buy from RxPayouts |
| Fioricet 40mg | 90 | $15.00 | $2.11ea | $189.95 | Buy from RxPayouts |
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Fioricet Information
Brand Name: Fioricet
Fioricet is a barbiturate sedative (butalbital) mixed with a non-aspirin pain medication (acetaminophen) and caffeine. This non-narcotic pain medication and relaxant is often prescribed for tension headaches caused by contractions of the muscles in the neck and shoulder area, and migraine.
Fioricet Ingredients and Composition
Each Fioricet tablet contains:
- butalbital 50 mg
- acetaminophen 325 mg
- caffeine 40 mg
Active Ingredients:
- butalbital
- USP
- acetaminophen
- caffeine
Inactive Ingredients:
- crospovidone
- FD&C Blue #1
- magnesium stearate
- microcrystalline cellulose
- povidone
- pregelatinized starch
- stearic acid
- Butalbital
- is a short to intermediate-acting barbiturate.
- Acetaminophen
- is a non- opiate, non-salicylate analgesic and antipyretic.
- Caffeine
- is a central nervous system stimulant.
How To Take Fioricet and Fioricet Dosage and Administration
- Take one to two tablets or capsules every four hours.
- 325-500 mg of acetaminophen per capsule or tablet; take a maximum of six capsules or tablets per day.
- 650 mg of acetaminophen per capsule or tablet; take a maximum of four capsules or tablets per day.
Higher doses of acetaminophen could increase the risk of severe liver toxicity. Do not exceed these guidelines without the express recommendation of your doctor.
Extended and repeated use of this product is not recommended because of the potential for physical dependence (addiction).
If you suspect a Fioricet Overdose
A Fioricet overdose, or combining this medication with alcohol or other central nervous system depressant, may lead to unconciousness or perhaps death. Butalbital overdose is indicated by severe drowsiness, confusion, extreme weakness, hallucination, shortness of breath, too slow or troubled breathing, slurred speech, lack of coordination, vomiting with blood, unusually slow heartbeat. Caffeine overdose is characterized by convulsions, diarrhea, sweating, frequent urination, ringing sounds in ears, muscle twitching or trembling, or seeing 'zig-zag' lights. Acetaminophen overdose can result in severe liver poisoning, but rarely has this effect in doses under 10g. An overdose of acetaminophen may not show symptoms for two to four days, but must be treated within twenty-for hours to prevent liver damage or death. Be alert to any signs of yellowing skin or eyes, or a sense of whole-body nausea.
Fioricet Side Effects
Frequently Observed and Mild Side Effects
The most frequently reported adverse reactions or side effects include:
- drowsiness
- light-headedness
- dizziness
- sedation
- shortness of breath
- nausea or vomiting (if it occurs without other symptoms of overdose)
- abdominal pain
- feeling of intoxication
Serious Fioricet Side Effects
These side effects should be reported to your doctor as soon as possible, and include:
- mild excitement (euphoria)
- depression
- mild confusion
- bloody or black stools
- bloody urine
- red pinpoints on skin
- painful or swollen glands
- unusual (mild) tiredness or weakness
- unusual bleeding or bruising
Contact a doctor immediately if you experience any of the following symptoms, and especially if you experience several together:
- bleeding sores on your lips
- chest pain
- fever
- large hive-like swellings on face or in mouth
- muscle cramping or pain
- thick or reddened skin
- scaly skin
- rash
- itching
- hives
- sores or ulcers in the mouth
- painful white spots in mouth
- sore throat
Infrequently Observed
All adverse events tabulated below are classified as infrequent.
Central Nervous: headache, shaky feeling, tingling, agitation, fainting, fatigue, heavy eyelids, high energy, hot spells, numbness, sluggishness, seizure. Mental confusion, excitement or depression can also occur due to intolerance, particularly in elderly or debilitated patients, or due to overdosage of butalbital.
Autonomic Nervous: dry mouth, hyperhidrosis.
Gastrointestinal: difficulty swallowing, heartburn, flatulence, constipation.
Cardiovascular: tachycardia.
Musculoskeletal: leg pain, muscle fatigue.
Genitourinary: diuresis.
Miscellaneous: pruritus, fever, earache, nasal congestion, tinnitus, euphoria, allergic reactions. Several cases of dermatological reactions, including toxic epidermal necrolysis and erythema multiforme, have been reported.
The following adverse drug events may be borne in mind as potential effects of the components of this product. Potential effects of high dosage are listed in the
Fioricet Overdose section.Acetaminophen: allergic reactions, rash, thrombocytopenia, agranulocytosis.
Caffeine:cardiac stimulation, irritability, tremor, dependence, nephrotoxicity, hyperglycemia.
Fioricet Drug Abuse and Dependence
$2: Barbiturates may be habit-forming.Tolerance, psychological dependence, and physical dependence may occur especially following prolonged use of high doses of barbiturates. The average daily dose for the barbiturate addict is usually about 1500 mg. As tolerance to barbiturates develops, the amount needed to maintain the same level of intoxication increases; tolerance to a fatal dosage, however, does not increase more than two- fold. As this occurs, the margin between an intoxication dosage and fatal dosage becomes smaller. The lethaldose of a barbiturate is far less if alcohol is also ingested.
Major withdrawal symptoms (convulsions and delirium) may occur within 16 hours and last up to 5 days after abrupt cessation of these drugs. Intensity of withdrawal symptoms gradually declines over a period of approximately 15 days. Treatment of barbiturate dependence consists of cautious and gradual withdrawal of the drug.
Barbiturate-dependent patients can be withdrawn by using a number of different withdrawal regimens. One method involves initiating treatment at the patient's regular dosage level and gradually decreasing the daily dosage as tolerated by the patient.
Fioricet Precautions and Contraindications
While Fioricet is a highly effective pain reliever, it has been associated with an increased risk of addiction when used improperly, or for too long. Never take Fioricet in greater doses, or for a longer period of time, than recommended by your doctor.
Fioricet may not be suitable for some patients, and some conditions require that this medication be taken in lower doses or with other precautions. Discuss a history of any of the following conditions with your doctor so that your treatment will be as safe as possible.
- Alcohol or drug abuse: You may be at an increased risk for liver damage or dependence.
- Allergic reaction to any barbiturate, acetaminophen, or caffeine: Do not take Fioricet.
- Asthma: Increased risk of serious side effects
- Depression: Butalbital may worsen this condition
- Diabetes (sugar): Butalbital may worsen this condition
- Heart disease: Caffeine may make certain heart conditions worse
- Hepatitis or other liver damage: Increased risk of serious side effects
- Hyperactivity (children): Increased risk of serious side effects
- Kidney disease: Increased risk of serious side effects
- Overactive thyroid: Butalbital may worsen this condition
- Porphyria: Butalbital is listed as an unsafe drug for porphyria, an enzyme deficiency that can cause fragile skin that is sensitive to sunlight, digestive difficulties, anxiety, and reddish-brown urine.
Fioricet Drug Interactions
Fioricet contains the central nervous system depressant butalbital, and may react strongly with other medication that has a similar effect. Be cautious about taking Fioricet with any medication that warns it 'may cause drowsiness' or cautions you against driving or operating heavy machinery. The acetaminophen in Fioricet should not be mixed with certain ingredients in other pain medication.
- Alcohol - Butalbital and alcohol can accelerate central nervous system depression. Avoid mixing Fioricet with alcohol, as this could result in a fatal overdose. Excessive drinking during Fioricet treatment may also increase the likelihood of serious liver damage or stomach bleeding.
- Antidiabetic drugs or insulin - Can cause hypoglycemia in combination, dosage adjustments may be required.
- Antihistamines like Benadryl or Tavist
- Anticoagulants or blood thinners
- Aspirin (or any salicylate, such as salicylamide, or salicylic acid) can cause kidney or liver damage when taken in high doses, and over long periods of time, in combination with acetaminophen. When taken in the recommended doses, for a short time, it has not been seen to produce this effect.
- Benzodiazepines (a class of antidepressants, anti-panic agents, and muscle relaxants) such as Ativan (lorazepam), Valium (diazepam), Halcion (triazolam), Restoril (temazepam), Librium(chlordiazepoxide), Xanax (alprazolam), Tranxene-SD (clorazepate), Paxipam (halazepam), ProSom (estazolam), Klonopin (clonazepam), and others, should be used cautiously with Fioricet.
- Beta Blockers - Drugs like Inderal (propranolol), Lopressor (metoprolol), Tenormin (atenolol), and others may become less effective treatments when used with barbiturates such as butalbital.
- Caffeine - As Fioricet contains caffeine, you should limit your intake of caffeine through coffee or over the counter stimulants such as Vivarin or NoDoz. Too much caffeine can cause rebound headaches and constipation as withdrawal symptoms.
- Corticosteroids (cortisone) - Fioricet may make these medications less effective.
- Corticotropin (ACTH) - Fioricet may make this medication less effective.
- Desyrel (trazodone) - Risk of additive CNS depression.
- MAO(Monoamine Oxidase) inhibitors - Fioricet must not be mixed with MAO (monoamine oxidase) inhibitors such as the antidepressants Nardil, Marplan, or Parnate.
- Narcotic pain medication, like Codeine, Demerol (meperidine), Buprenex (buprenorphine), Darvon (propoxyphene), Dilaudid (hydromorphone), MS Contin or Kadian (morphine), nalbuphine, OxyContin (oxycodone), Percocet (oxycodone, acetaminophen), Stadol (butorphanol), Talwin compound (pentazocine), Vicodin (hydrocodone, acetaminophen), or Vicoprofen (hydrocodone, ibuprofen) should not be mixed with Fioricet.
- Norflex (orphenadrine) - Risk of oversedation.
- Oral contraceptives - Butalbital may make these medications less effective.
- Sedatives like Fiorinal, Phenobarbitol, Seconal, or barbiturates of any other kind, should not be mixed with butalbital.
- Sleep medication like Ambien (zolpidem), Sonata (zaleplon), or over the counter sleeping pills should be used with butalbital only as, and if, advised by your doctor.
- Skeletal muscle relaxants - such as Flexeril (cyclobenzaprine), Skelaxin (metaxalone), Soma (carisoprodol), or Robaxin (methocarbamol) should not be mixed with Fioricet.
- Street drugs, such as barbiturates or opiates, must never be mixed with Fioricet as this could result in a fatal overdose.
- Tegretol (carbamazepine)
- Tranquilizers such as Haldol (haloperidol), Mellaril (thioridazine), or Thorazine (chlorpromazine) may cause oversedation; they should not be mixed with butalbital.
- Tricyclic antidepressants such as Elavil (amitriptyline), Asendin (amoxapine), Anafranil (clomipramine), Pertofrane or Norpramin (desipramine), Sinequan (doxepin), Tofranil (imipramine), Aventyl or Pamelor (nortriptyline), Vivactil (protriptyline), and Surmontil (trimipramine), may increase the central nervous system suppressant effects from either the antidepressant, or the Fioricet.
- Valproic acid, also Depakote, Depakene, divalproex.
- Wellbutrin/Zyban (bupropion) - Barbiturates such as butalbital may decrease levels of bupropion in the body.
The CNS effects of butalbital may be enhanced by monoamine oxidase (MAO(Monoamine Oxidase)) inhibitors. Butalbital, acetaminophen and caffeine may enhance the effects of: other narcotic analgesics, alcohol, general anesthetics, tranquilizers such as chlordiazepoxide, sedative-hypnotics, or other CNS depressants, causing increased CNS depression.
Drug/Laboratory Test Interactions
Acetaminophen may produce false-positive test results for urinary 5-hydroxyindoleacetic acid.
Taking Fioricet during Pregnancy or Breast-feeding
Fioricet is not recommended for pregnant or nursing women, as its components can affect a developing infant. Barbiturates have been shown to increase the risk of birth defects and brain tumors in the fetus. Caffeine in large doses may interfere with the baby's heart rhythm and growth.
If you become pregnant while taking this medication, inform your doctor immediately. If you are breastfeeding, your doctor will advise you to stop breastfeeding if you must take Fioricet.
Fioricet Addiction and Abuse
Barbiturates may be habit-forming: Tolerance, psychological dependence, and physical dependence may occur especially following prolonged use of high doses of barbiturates. The average daily dose for the barbiturate addict is usually about 1500 mg. As tolerance to barbiturates develops, the amount needed to maintain the same level of intoxication increases; tolerance to a fatal dosage, however, does not increase more than two- fold. As this occurs, the margin between an intoxication dosage and fatal dosage becomes smaller. The lethaldose of a barbiturate is far less if alcohol is also ingested. Major withdrawal symptoms (convulsions and delirium) may occur within 16 hours and last up to 5 days after abrupt cessation of these drugs. Intensity of withdrawal symptoms gradually declines over a period of approximately 15 days. Treatment of barbiturate dependence consists of cautious and gradual withdrawal of the drug. Barbiturate-dependent patients can be withdrawn by using a number of different withdrawal regimens. One method involves initiating treatment at the patient's regular dosage level and gradually decreasing the daily dosage as tolerated by the patient.
Storing Fioricet
Store below 30°C (86°F).
Additional Notes
Fioricet has not been tested for safety in children under the age of 12. Older children might be prescribed a reduced dose.
Articles and information related to Fioricet
- Migraine
Credits for Fioricet Information
Fioricet information on this page is copyright by Drug Information at Pharma-Help.com, reprinted with Permission. All Rights Reserved. Other pages with reprint permission include Fioricet.