Table Of Contents
- Famvir Price Comparison Table
- Famvir Information
- Famvir Ingredients and Composition
- How Does Famvir Work?
- How To Take Famvir and Famvir Dosage and Administration
- If you suspect a Famvir Overdose
- Famvir Side Effects
- Famvir Precautions and Contraindications
- Taking Famvir during Pregnancy or Breast-feeding
- Contraindications to Famvir
- Famvir Drug Interactions
- Famvir Clinical Trials and Studies
- Storing Famvir
- Additional Patient Information for Famvir
- Credits for Famvir Information
Brand names: Famvir
Famvir Price Comparison Table
| Product | Qty | Medical Fees & Shipping | Price/ Qty | Price | Click to Order |
|---|---|---|---|---|---|
| Famvir 500mg | 21 | $10.95 | $5.41ea | $113.51 | Buy from PharmaWebCanada |
| Famvir 500mg | 30 | $18.00 | $9.50ea | $285.00 | Buy from JRB |
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| Famvir 500mg | 60 | $18.00 | $8.15ea | $489.00 | Buy from IntegraRx |
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Famvir 500mg| Product | Qty | Medical Fees & Shipping | Price/ Qty | Price | Click to Order |
|---|---|---|---|---|---|
| Famvir 250mg | 30 | $10.95 | $3.06ea | $91.77 | Buy from PharmaWebCanada |
| Famvir 250mg | 30 | $18.00 | $5.50ea | $165.00 | Buy from JRB |
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| Famvir 250mg | 60 | $18.00 | $4.45ea | $267.00 | Buy from IntegraRx |
| Famvir 250mg | 60 | $18.00 | $4.75ea | $285.00 | Buy from JRB |
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| Famvir 250mg | 90 | $18.00 | $4.06ea | $365.00 | Buy from IntegraRx |
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| Product | Qty | Medical Fees & Shipping | Price/ Qty | Price | Click to Order |
|---|---|---|---|---|---|
| Famvir 125mg | 10 | $10.95 | $2.70ea | $26.99 | Buy from PharmaWebCanada |
| Famvir 125mg | 30 | $18.00 | $5.17ea | $155.00 | Buy from JRB |
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| Famvir 125mg | 30 | $15.00 | $6.13ea | $184.00 | Buy from RxPayouts |
| Famvir 125mg | 60 | $18.00 | $4.15ea | $249.00 | Buy from IntegraRx |
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| Famvir 125mg | 60 | $18.00 | $4.65ea | $279.00 | Buy from MPllc |
| Famvir 125mg | 60 | $15.00 | $4.75ea | $285.00 | Buy from RxPayouts |
| Famvir 125mg | 90 | $18.00 | $3.77ea | $339.00 | Buy from IntegraRx |
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| Famvir 125mg | 90 | Free Shipping | $4.23ea | $381.00 | Buy from MPllc |
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Famvir Information
Herpes Zoster
Famvir (famciclovir) is indicated for the treatment of acute herpes zoster (shingles).
Herpes Simplex Infections
Famvir is indicated for:
- treatment or suppression of recurrent genital herpes in immunocompetent patients
- treatment of recurrent mucocutaneous herpes simplex infections in HIV infected patients.
Famvir Ingredients and Composition
Famvir contains famciclovir, an orally administered prodrug of the antiviral agent penciclovir. Chemically, famciclovir is known as 2-[2-(2-amino-9H-purin-9-yl)ethyl]-1,3-propanediol diacetate. Its molecular formula is C14H19N55O4 ; its molecular weight is 321.3. It is a synthetic acyclic guanine derivative.
Famciclovir, the active ingredient in Famvir, is a white to pale yellow solid. It is freely soluble in acetone and methanol, and sparingly soluble in ethanol and isopropanol. At 25°C famciclovir is freely soluble (>25% w/v) in water initially, but rapidly precipitates as the sparingly soluble (2-3% w/v) monohydrate. Famciclovir is not hygroscopic below 85% relative humidity. Partition coefficients are: octanol/water (pH 4.8) P=1.09 and octanol/phosphate buffer (pH 7.4) P=2.08.
Famvir Tablets for Oral Administration: Each white, film-coated tablet contains famciclovir. The 125 mg and 250 mg tablets are round; the 500 mg tablets are oval.
Inactive ingredients of Famvir Tablets are:
- hydroxypropyl cellulose
- hydroxypropyl methylcellulose
- lactose
- magnesium stearate
- polyethylene glycols
- sodium starch glycolate
- titanium dioxide
How Does Famvir Work?
Mechanism of Famvir Antiviral Activity
Famciclovir, the active ingredient in Famvir, undergoes rapid biotransformation to the active antiviral compound penciclovir, which has inhibitory activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) and varicella zoster virus (VZV). In cells infected with HSV-1, HSV-2 or VZV, viral thymidine kinase phosphorylates penciclovir to a monophosphate form that, in turn, is converted to penciclovir triphosphate by cellular kinases. In vitro studies demonstrate that penciclovir triphosphate inhibits HSV-2 DNA polymerase competitively with deoxyguanosine triphosphate. Consequently, herpes viral DNA synthesis and, therefore, replication are selectively inhibited.
Penciclovir triphosphate has an intracellular half-life of 10 hours in HSV-1-,20 hours in HSV-2- and 7 hours in VZV-infected cells cultured in vitro; however, the clinical significance is unknown.
HIV-lnfected Patients
Following oral administration of a single dose of 500 mg Famvir (famciclovir) (the oral prodrug of penciclovir) to HIV-positive patients, the pharmacokinetic parameters of penciclovir were comparable to those observed in healthy subjects.
How To Take Famvir and Famvir Dosage and Administration
Herpes Zoster
The recommended Famvir dosage is 500 mg every 8 hours for 7 days. Therapy should be initiated promptly as soon as herpes zoster is diagnosed. No data are available on efficacy of treatment started greater than 72 hours after rash onset.
Herpes Simplex Infections
Recurrent genital herpes: The recommended Famvir dosage is 125 mg twice daily for 5 days. Initiate therapy at the first sign or symptom if medical management of a genital herpes recurrence is indicated. The efficacy of Famvir has not been established when treatment is initiated more than 6 hours after onset of symptoms or lesions. Suppression of recurrent genital herpes: The recommended Famvir dosage is 250 mg twice daily for up to 1 year. The safety and efficacy of Famvir therapy beyond 1 year of treatment have not been established. HIV-Infected Patients: For recurrent orolabial or genital herpes simplex infection, the recommended Famvir dosage is 500 mg twice daily for 7 days. In patients with reduced renal function, dosage reduction is recommended. Administration with Food: When famciclovir was administered with food, penciclovir Cmax decreased approximately 50%. Because the systemic availability of penciclovir (AUC) was not altered, it appears that Famvir may be taken without regard to meals.If you suspect a Famvir Overdose
Appropriate symptomatic and supportive therapy should be given. Famvir (famciclovir) is removed by hemodialysis.
Famvir Side Effects
Immunocompetent Patients
The safety of Famvir has been evaluated in clinical studies involving 816 Famvir-treated patients with herpes zoster (Famvir, 250 mg t.i.d. to 750 mg t.i.d.); 528 Famvir-treated patients with recurrent genital herpes (Famvir, 125 mg b.i.d. to 500 mg t.i.d.); and 1,197 patients with recurrent genital herpes treated with Famvir as suppressive therapy (125 mg q.d. to 250 mg t.i.d.) of which 570 patients received Famvir (open-labeled and/or double-blind) for at least 10 months. Selected Famvir side effects are listed below:
Nervous System:
- Headache
- Paresthesia
- Migraine
Gastrointestinal:
- Nausea
- Diarrhea
- Vomiting
- Flatulence
- Abdominal Pain
Body as a Whole:
- Fatigue
Skin and Appendages:
- Pruritus
- Rash
Reproductive Female:
- Dysmenorrhea
HIV-lnfected Patients
In HIV-infected patients, the most frequently reported Famvir side effects (500 mg twice daily; n=150) and acyclovir side effects(400 mg, 5x/day; n=143), respectively, were headache (16.0 vs 15.4%), nausea (10.7 vs 12.6%), diarrhea (6.7 vs 10.5%), vomiting(4.7 vs 3.5%), fatigue (4.0 vs 2.1%), and abdominal pain(3.3 vs 5.6%).
Famvir Precautions and Contraindications
General
The efficacy of Famvir has not been established for initial episode genital herpes infection, ophthalmic zoster, disseminated zoster or in immunocompromised patients with herpes zoster.
Dosage adjustment is recommended when administering Famvir to patients with creatinine clearance values <60 mL/min. In patients with underlying renal disease who have received inappropriately high doses of Famvir for their level of renal function, acute renal failure has been reported.
Taking Famvir during Pregnancy or Breast-feeding
Following oral administration of Famvir (famciclovir) to lactating rats, penciclovir was excreted in breast milk at concentrations higher than those seen in the plasma. It is not known whether it is excreted in human milk. There are no data on the safety of Famvir in infants.
Contraindications to Famvir
Famvir (famciclovir) is contraindicated in patients with known hypersensitivity to the product, its components, and Denavir (penciclovir cream).
Famvir Drug Interactions
Concurrent Famvir use with probenecid or other drugs significantly eliminated by active renal tubular secretion may result in increased plasma concentrations of penciclovir.
The conversion of 6-deoxy penciclovir to penciclovir is catalyzed by aldehyde oxidase. Interactions with other drugs metabolized by this enzyme could potentially occur.
Famvir Clinical Trials and Studies
Herpes Zoster
Famvir (famciclovir) was studied in a placebo-controlled, double-blind trial of 419 immunocompetent adults with uncomplicated herpes zoster. Comparisons included Famvir 500 mg t.i.d., Famvir 750 mg t.i.d., or placebo. Treatment was begun within 72 hours of initial lesion appearance and therapy was continued for 7 days.
The median time to full crusting in Famvir-treated patients was 5 days compared to 7 days in placebo-treated patients. The times to full crusting, loss of vesicles, loss of ulcers, and loss of crusts were shorter for Famvir 500 mg treated patients than for placebo-treated patients in the overall study population. The effects of Famvir were greater when therapy was initiated within 48 hours of rash onset; it was also more pronounced in patients 50 years of age or older. Among the 65.2% of patients with at least one positive viral culture, Famvir-treated patients had a shorter median duration of viral shedding than placebo-treated patients (1 day and 2 days, respectively).
There were no overall differences in the duration of pain before rash healing between Famvir and placebo-treated groups. In addition, there was no difference in the incidence of pain after rash healing (postherpetic neuralgia) between the treatment groups. In the 186 patients (44.4% of total study population) who did develop postherpetic neuralgia, the median duration of postherpetic neuralgia was shorter in patients treated with Famvir 500 mg than in those treated with placebo (63 days and 119 days, respectively). No additional efficacy was demonstrated with higher doses of Famvir.
A double-blind controlled trial in 545 immunocompetent adults with uncomplicated herpes zoster treated within 72 hours of initial lesion appearance compared three doses of Famvir to acyclovir 800 mg 5 times per day. Times to full lesion crusting and times to loss of acute pain were comparable for all groups and there were no statistically significant differences in the time to loss of postherpetic neuralgia between Famvir and acyclovir-treated groups.
Herpes Simplex Infections
Recurrent Genital Herpes: In two placebo-controlled trials, 626 immunocompetent adults with a recurrence of genital herpes were treated with Famvir 125 mg b.i.d.(n=160), Famvir 250 mg b.i.d.(n=169), Famvir 500 mg b.i.d.(n=154) or placebo (n=143) for 5 days. Treatment was initiated within 6 hours of either symptom onset or lesion appearance. In the two studies combined, the median time to healing in Famvir 125 mg-treated patients was 4 days compared to 5 days in placebo-treated patients and the median time to cessation of viral shedding was 1.8 vs. 3.4 days in Famvir 125 mg and placebo recipients, respectively. The median time to loss of all symptoms was 3.2 days in Famvir 125 mg-treated patients vs. 3.8 days in placebo-treated patients. No additional efficacy was demonstrated with higher doses of Famvir Suppression of Recurrent Genital Herpes: 934 immunocompetent adults with a history of 6 or more recurrences per year were randomized into two double-blind, 1-year, placebo-controlled trials. Comparisons included Famvir 125 mg t.i.d., 250 mg b.i.d., 250 mg t.i.d. and placebo. At one-year, 60% to 65% of patients were still receiving Famvir and 25% were receiving placebo treatment. Recurrent Mucocutaneous Herpes Simplex Infection in HIV-lnfected Patients: A randomized, double-blind, multicenter study compared Famvir (famciclovir) 500 mg twice daily for 7 days (n=150) with oral acyclovir 400 mg 5 times daily for 7 days (n=143) in HIV-infected patients with recurrent mucocutaneous HSV infection treated within 48 hours of lesion onset. Approximately 40% of patients had a CD4 count below 200 cells/mm3 ,54% of patients had anogenital lesions and 35% had orolabial lesions. Famvir (famciclovir) therapy was comparable to oral acyclovir in reducing new lesion formation and in time to complete healing.Storing Famvir
Store between 15° and 30° C (59° and 86° F).
Additional Patient Information for Famvir
Patients should be informed that Famvir is not a cure for genital herpes. There are no data evaluating whether Famvir will prevent transmission of infection to others. As genital herpes is a sexually transmitted disease, patients should avoid contact with lesions or intercourse when lesions and/or symptoms are present to avoid infecting partners. Genital herpes can also be transmitted in the absence of symptoms through asymptomatic viral shedding. If medical management of recurrent episodes is indicated, patients should be advised to initiate Famvir therapy at the first sign or symptom.
Credits for Famvir Information
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