Table Of Contents
- Condylox Price Comparison Table
- Condylox Information
- Condylox Ingredients and Composition
- How Does Condylox Work?
- How To Take Condylox and Condylox Dosage and Administration
- If you suspect a Condylox Overdose
- Condylox Side Effects
- Condylox Warnings
- Condylox Precautions and Contraindications
- Contraindications to Condylox
- Condylox Clinical Trials and Studies
- Condylox Pill Identification / ID and Appearance
- Storing Condylox
- Additional Patient Information for Condylox
- Credits for Condylox Information
Condylox Price Comparison Table
| Product | Qty | Medical Fees & Shipping | Price/ Qty | Price | Click to Order |
|---|---|---|---|---|---|
| Condylox 3.5ml 5% Solution | 1 | $18.00 | $179.95ea | $179.95 | Buy from JRB |
| Condylox 3.5ml 5% Solution | 2 | $18.00 | $149.97ea | $299.95 | Buy from JRB |
| Product | Qty | Medical Fees & Shipping | Price/ Qty | Price | Click to Order |
|---|---|---|---|---|---|
| Condylox gel 3.5gm | 1 | $18.00 | $216.00ea | $216.00 | Buy from Billing-md |
| Product | Qty | Medical Fees & Shipping | Price/ Qty | Price | Click to Order |
|---|---|---|---|---|---|
| Condylox Sol 3.5ml | 1 | $18.00 | $180.00ea | $180.00 | Buy from Billing-md |
| Product | Qty | Medical Fees & Shipping | Price/ Qty | Price | Click to Order |
|---|---|---|---|---|---|
| Condylox 3.5gm 5% Gel | 1 | $18.00 | $229.95ea | $229.95 | Buy from JRB |
| Condylox 3.5gm 5% Gel | 2 | $18.00 | $199.97ea | $399.95 | Buy from JRB |
| Product | Qty | Medical Fees & Shipping | Price/ Qty | Price | Click to Order |
|---|---|---|---|---|---|
| Condylox Solution 0.5% | 1 | $18.00 | $220.00ea | $220.00 | Buy from MPllc |
| Condylox Solution 0.5% | 2 | $18.00 | $189.50ea | $379.00 | Buy from MPllc |
| Product | Qty | Medical Fees & Shipping | Price/ Qty | Price | Click to Order |
|---|---|---|---|---|---|
| Condylox Gel 0.5% | 1 | $18.00 | $234.00ea | $234.00 | Buy from MPllc |
| Condylox Gel 0.5% | 2 | $18.00 | $196.50ea | $393.00 | Buy from MPllc |
| Product | Qty | Medical Fees & Shipping | Price/ Qty | Price | Click to Order |
|---|---|---|---|---|---|
| Condylox gel 0.50% | 1 | $15.00 | $205.00ea | $205.00 | Buy from RxPayouts |
| Condylox gel 0.50% | 3 | $15.00 | $178.33ea | $535.00 | Buy from RxPayouts |
| Product | Qty | Medical Fees & Shipping | Price/ Qty | Price | Click to Order |
|---|---|---|---|---|---|
| Condylox 0.50% | 1 | $15.00 | $132.50ea | $132.50 | Buy from RxPayouts |
| Condylox 0.50% | 3 | $15.00 | $134.33ea | $403.00 | Buy from RxPayouts |
| Product | Qty | Medical Fees & Shipping | Price/ Qty | Price | Click to Order |
|---|---|---|---|---|---|
| Condylox solution 0.50% | 1 | $15.00 | $192.00ea | $192.00 | Buy from RxPayouts |
| Condylox solution 0.50% | 3 | $15.00 | $192.00ea | $576.00 | Buy from RxPayouts |
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Condylox Information
Brand Name: Condylox
Generic Names: Podofilox
Other Common Names: Podofilia #2
Condylox Gel 0.5% is indicated for the topical treatment of anogenital warts (external genital warts and perianal warts). This product is not indicated in the treatment of mucous membrane warts.
Diagnosis
Although anogenital warts have a characteristic appearance, histopathologic confirmation should be obtained if there is any doubt of the diagnosis. Differentiating warts from squamous cell carcinoma "Bowenoid papulosis" is of particular concern. Squamous cell carcinoma may also be associated with human papillomavirus which should not be treated with Condylox Gel 0.5%.
Condylox Ingredients and Composition
Podofilox, the active ingredient in Condylox, is an antimitotic drug which can be chemically synthesized or purified from the plant families Coniferae and Benberidaceae (e.g. species of Juniperus and Podophyllum). Condylox Gel 0.5% is formulated for topical administration. Each gram of gel contains 5mg of podofilox in a buffered alcoholic gel containing alcohol, glycerin, lactic acid, hydroxypropyl cellulose, sodium lactate, and butylated hydroxytoluene.
Podofilox, the active ingredient in Condyloxs has a molecular weight of 414.4 daltons, and is soluble in alcohol and sparingly soluble in water. Its chemical name is [5R(5a,5a13,8aa,9cx]-5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5- trimethoxyphenyl) furo[3',4': 6,7] naphtho-[2,3,-d]-1,3-dioxol-6(5aH) one.
How Does Condylox Work?
Mechanism of Action
Treatment of anogenital warts with podofilox results in necrosis of visible wart tissue. The exact mechanism of Condylox action is unknown.
Pharmacokinetics
In systemic absorption studies in 52 patients, topical application of 0.05mL of an ethanolic solution containing 0.5% podofilox to external genitalia did not result in detectable serum levels. Applications of 0.1 to 1.5mL resulted in peak serum levels of 1 to 17 ng/mL one to two hours after application. The elimination half-life ranged from 1.0 to 4.5 hours. The drug was not found to accumulate after multiple treatments.
How To Take Condylox and Condylox Dosage and Administration
The prescriber should ensure that the patient is fully aware of the correct method of therapy and identify which specific warts should be treated.
Apply Condylox twice daily for 3 consecutive days, then discontinue for 4 consecutive days. This one week cycle of treatment may be repeated until there is no visible wart tissue or for a maximum of four cycles. If there is incomplete response after four treatment cycles, discontinue treatment and consider alternative treatment. Safety and effectiveness of more than four treatment cycles has not been established. There is no evidence to suggest that more frequent application will increase efficacy, but additional Condylox applications would be expected to increase the rate of local adverse reactions and systemic absorption.
Condylox Gel 0.5% should be applied to the warts with the applicator tip or finger. Application on the surrounding normal tissue should be minimized. Treatment should be limited to 10 cm2 or less of wart tissue and to no more than 0.5g of the gel per day.
Care should be taken to allow the gel to dry before allowing the return of opposing skin surfaces to their normal positions. Patients should be instructed to wash their hands thoroughly before and after each Condylox application.
If you suspect a Condylox Overdose
Topically applied Condylox may be absorbed systemically. Toxicity reported following systemic administration of Condylox in investigational use for cancer treatment included: nausea, vomiting, fever, diarrhea, bone marrow depression, and oral ulcers. Following 5 to 10 daily intravenous doses of 0.5 to 1 mg/kg/day, significant hematological toxicity occurred but was reversible. Other toxicities occurred at lower doses. Treatment of topical overdosage should include washing the skin free of any remaining drug and symptomatic and supportive therapy.
Condylox Side Effects
In clinical trials with Condylox Gel 0.5%, the following local side effects were reported during the treatment of anogenital warts. The severity of local side effects were predominantly mild or moderate and did not increase during the treatment period. Severe reactions were most frequent within the first 2 weeks of treatment.
- Inflammation
- Burning
- Erosion
- Pain
- Itching
- Bleeding
Other local Condylox side effects reported included stinging (7%), and erythema (5%); less commonly reported local adverse events included desquamation, scabbing, discoloration, tenderness, dryness, crusting, fissures, soreness, ulceration, swelling/edema, tingling, rash, and blisters.
The most common systemic adverse event reported during the clinical studies was headache (7%).
As with any medication, you may experience additional unreported Condylox side effects.
Condylox Warnings
Correct diagnosis of the lesions to be treated is essential.
Condylox Gel 0.5% is intended for cutaneous use only. Avoid contact with the eyes. If contact with the eyes occurs, patients should immediately flush the eyes with copious quantities of water and seek medical advice.
Condylox is flammable. Keep away from open flame.
Condylox Precautions and Contraindications
General
Data is not available on the safe and effective use of Condylox for treatment of warts occurring on mucous membranes of the genital area (including the urethra, rectum and vagina). The recommended method of application, frequency of application, and duration of usage should not be exceeded.
Contraindications to Condylox
Condylox Gel 0. 5% is contraindicated for patients who develop hypersensitivity or intolerance to any components of the formulation.
Condylox Clinical Trials and Studies
In the first multicenter clinical study in 326 patients with anogenital warts, Condylox Gel 0.5% and its vehicle were applied in a double-blind fashion to comparable patient groups. Of the 260 patients with efficacy data, 176 were treated with Condylox Gel 0.5%. Patients applied Condylox Gel 0.5% twice daily for three consecutive days followed by a 4 day "rest" period.
At the end of 4 weeks, 38.4% of the patients had complete clearing of the wart tissue when treated with Condylox Gel 0.5%.
In the second multicenter clinical trial in 108 evaluable patients with anogenital warts, Condylox (podofilox) Topical Solution 0.5% was compared with Condylox Gel 0.5% for efficacy. As in the first clinical trial, patients applied Condylox Gel 0.5% twice daily for three consecutive days followed by a four day "rest" period.
Similar clearance rates were observed. At the end of 4 weeks, 25.6% of the patients had complete clearing of the wart tissue when treated with Condylox Gel 0.5%.
Condylox Pill Identification / ID and Appearance
Condylox Gel 0.5% is supplied as 3.5g of clear gel in aluminum tubes with an applicator tip. NDC55515-102-01.
Storing Condylox
Store at controlled room temperature between 15°- 30°C (59°- 86° F ).
Avoid excessive heat. Do not freeze.
Additional Patient Information for Condylox
Patients using Condylox Gel 0.5% should receive the following information and instructions. This information is intended to aid in the safe and effective use of this medication. It is not intended to disclose all possible adverse or intended effects.
- Condylox should be used only as directed by the health care provider. Patients should be instructed to wash their hands thoroughly before and after each application. It is for external use only. Avoid contact with the eyes.
- Patients should be advised not to use this medication for any disorder other than for which it was prescribed.
- Patients should report any signs of adverse reactions to the health care provider.
- If no improvement is observed after 4 weeks of treatment, discontinue Condylox and consult the health care provider.
Credits for Condylox Information
Condylox information on this page is copyright by Drug Information at Pharma-Help.com, reprinted with Permission. All Rights Reserved. Other pages with reprint permission include Condylox.